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Cardiomyopathy was reported in a few Duchenne muscular dystrophy(DMD) carriers with clinical evidence of myopathy.We report two carriers with dilated cardiomyopathy,increased serum CK,and no symptoms of muscle weakness.In heart biopsies of both patients,dystrophin-the protein product of DMD locus-was absent in many fibers.Dilated cardiomyopathy may be the only manifestation of gene mutation in carriers. |
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